I had a couple of minor issues with my Intel Mac Mini after the 10.4.10 update. Neither was apparent right away.
The first was my wireless network settings were lost. I had to go through the connect wizard and reconfigure the wireless network connection. This just involved entering the name (I don’t broadcast the wireless network name) and WPA password. It wasn’t a big deal. It’s also not the first time I’ve had to do this on the Mini so it may have been a coincidence and not caused by the update itself. The Mac Mini uses the built-in Airport and my WAP is a 2Wire 2701HG-B.
The other issues was with a 3rd party application I use. I use Remote Buddy by Iospirit to power the Apple remote. The software loaded fine after the update but failed to work. If I unloaded the software the remote worked fine with Front Row. There’s a new version of Remote Buddy and one of the fixes noted is “Improved Compatibility with OS X 10.4.10”. It was released June 21st. Once I installed the upgrade the Apple remote worked just fine.